Binghamton University Assistant Prof. Leads Drug Delivery Research

A Binghamton University assistant professor is investigating technology for the treatment of cancer and autoimmune disorders through the delivery of drugs through antibodies.

Binghamton University says L. Nathan Tumey, assistant professor of pharmaceutical sciences is the leading investigator on two National Institute of Health Grants totaling over $1.3 million to research antibody-mediated drug delivery technology.

So far, Tumey and his collaborators have found a way to attach drugs to a certain area of an antibody: the Glutamine 295 residue, without having to engineer the antibody or make changes to its “backbone.”

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According to a news release from the University, Tumey is the sole investigator on a two-year, $150,000 grant, charmingly entitled “Molecular whack-a-mole” Targeting Transmembrane-TNF alpha for the Delivery of Anti-Inflammatory Drugs.

Professor Tumey says the project is about developing antibody-drug-conjugates that deliver immunosuppressive drugs using antibodies against a particular protein that is only found in inflamed cells hoping to calm that inflammation down.